Gobbel G T, Cann C E, Fike J R
Department Neurological Surgery, School of Medicine, University of California, San Francisco 94143.
AJNR Am J Neuroradiol. 1993 May-Jun;14(3):543-50.
To compare an ultrafast CT method for estimating regional cerebral blood flow with a more commonly used xenon-enhanced CT method.
Xenon CT and ultrafast CT were used to estimate regional cerebral blood flow (rCBF) in 12 healthy beagle dogs. Measurements were obtained for left and right hemisphere, cortical gray matter, basal ganglia, and deep white matter. The ability of each method to show differences in blood flow between regions of high flow (gray matter) and low flow (white matter) was evaluated, both for large (> 0.75 cm3) and small (< 0.5 cm3) regions of interest. In addition, side-to-side differences in rCBF were evaluated to determine the minimum difference that would suggest a significant alteration in blood flow.
There was less interanimal variance in absolute rCBF measurements obtained using xenon CT; ultrafast CT appeared to accentuate rCBF differences between high flow and low flow regions. There were strong side-to-side correlations in rCBF when measured by ultrafast CT, which suggests that this technique may be particularly useful in detecting focal alterations in rCBF restricted to one hemisphere of the brain.
Ultrafast CT measures of rCBF compare favorably with those obtained using xenon CT.
比较一种用于估计局部脑血流量的超快CT方法与一种更常用的氙增强CT方法。
使用氙CT和超快CT对12只健康的比格犬进行局部脑血流量（rCBF）估计。对左、右半球、皮质灰质、基底神经节和深部白质进行测量。评估了每种方法在大（>0.75 cm³）和小（<0.5 cm³）感兴趣区域显示高血流量区域（灰质）和低血流量区域（白质）之间血流量差异的能力。此外，评估了rCBF的左右差异，以确定表明血流量有显著改变的最小差异。
使用氙CT获得的绝对rCBF测量值的动物间差异较小；超快CT似乎加剧了高血流量和低血流量区域之间的rCBF差异。通过超快CT测量时，rCBF存在很强的左右相关性，这表明该技术在检测局限于大脑一个半球的rCBF局灶性改变方面可能特别有用。
超快CT测量的rCBF与使用氙CT获得的结果相比具有优势。
