Touho H, Karasawa J, Ohnishi H, Yamada K, Shibamoto K, Ueda S
Department of Neurosurgery, Osaka Neurological Institute, Japan.
AJNR Am J Neuroradiol. 1993 May-Jun;14(3):655-60.
To investigate a new hemodynamic parameter that can be obtained by dynamic CT and that reflects cerebral blood flow (CBF), in patients with ischemic cerebrovascular disease.
CBF and hemodynamic parameters including the area under the time-dependent contrast-medium dilution curve (A) and mean transit time (MTT) were measured in 23 patients with ischemic cerebrovascular disease. They included 17 patients in the chronic stage (more than 1 month after onset) and six with acute occlusion of the internal carotid or middle cerebral artery (within 24 hours of onset). CBF measurement was conducted by inhalation of stable xenon during CT scan and the hemodynamic study was performed using dynamic CT.
CBF in the territory of the middle cerebral artery had an inverse correlation with MTT. (A) divided by (MTT) defined as (f) had a significantly positive correlation with CBF (MTT = 18.66 - 0.495.CBF + 0.005.CBF2, r = .730, P < .001).
This parameter (f) is thought to represent a relative CBF and it can be used in evaluation of the hemodynamic status in ischemic cerebrovascular disease.
在缺血性脑血管病患者中研究一种可通过动态CT获得并反映脑血流量（CBF）的新血流动力学参数。
对23例缺血性脑血管病患者测量CBF及血流动力学参数，包括时间依赖性造影剂稀释曲线下面积（A）和平均通过时间（MTT）。其中包括17例慢性期患者（发病1个月后）和6例颈内动脉或大脑中动脉急性闭塞患者（发病24小时内）。在CT扫描期间通过吸入稳定氙进行CBF测量，并使用动态CT进行血流动力学研究。
大脑中动脉供血区域的CBF与MTT呈负相关。（A）除以（MTT）定义为（f），其与CBF呈显著正相关（MTT = 18.66 - 0.495·CBF + 0.005·CBF2，r = 0.730，P < 0.001）。
该参数（f）被认为代表相对CBF，可用于评估缺血性脑血管病的血流动力学状态。
