胰高血糖素治疗改善硝苯地平中毒

Amelioration of nifedipine poisoning associated with glucagon therapy.

作者信息

Walter F G, Frye G, Mullen J T, Ekins B R, Khasigian P A

机构信息

Department of Emergency Medicine, Valley Medical Center, San Francisco.

出版信息

Ann Emerg Med. 1993 Jul;22(7):1234-7. doi: 10.1016/s0196-0644(05)80998-9.

DOI:10.1016/s0196-0644(05)80998-9

PMID:8517581

Abstract

Glucagon relieves calcium channel blocker-induced hypotension in animal studies. There are no published case reports of glucagon relieving hypotension in patients with calcium channel blocker poisoning. We describe a patient who developed hypotension after ingestion of 900 mg nifedipine. Therapy with IV lactated Ringer's solution and calcium chloride alone did not relieve his hypotension. However, hypotension rapidly resolved after the addition of IV glucagon therapy. This is the first case report of glucagon therapy at least temporally associated with relief of hypotension in a patient with calcium channel blocker poisoning. More research is needed to determine the appropriate role for glucagon in treating patients with calcium channel blocker poisoning.

摘要

在动物研究中，胰高血糖素可缓解钙通道阻滞剂引起的低血压。目前尚无关于胰高血糖素缓解钙通道阻滞剂中毒患者低血压的病例报告发表。我们描述了一名摄入900毫克硝苯地平后出现低血压的患者。单独使用静脉注射乳酸林格氏液和氯化钙治疗未能缓解其低血压。然而，在加用静脉注射胰高血糖素治疗后，低血压迅速得到缓解。这是首例关于胰高血糖素治疗至少在时间上与钙通道阻滞剂中毒患者低血压缓解相关的病例报告。需要更多研究来确定胰高血糖素在治疗钙通道阻滞剂中毒患者中的适当作用。