Wolf L R, Spadafora M P, Otten E J
Department of Emergency Medicine, Wright State University School of Medicine, Dayton, Ohio.
Ann Emerg Med. 1993 Jul;22(7):1225-8. doi: 10.1016/s0196-0644(05)80996-5.
Hypotension resulting from calcium channel blocker ingestion often is refractory to standard therapeutic modalities. Amrinone and glucagon have been used separately and in combination with other agents in the treatment of calcium channel blocker overdose. We report the successful use of both amrinone and glucagon in the treatment of a 30-year-old woman who ingested 3.6 g of verapamil and presented with refractory hypotension. The use of the two agents together may provide improved inotropic support with minimal increases in myocardial oxygen consumption. In this case, the combination of amrinone and glucagon was safe and effective in the management of the hemodynamic instability associated with calcium channel blocker overdose.
因摄入钙通道阻滞剂导致的低血压通常对标准治疗方式无效。氨力农和胰高血糖素已被单独使用，并与其他药物联合用于治疗钙通道阻滞剂过量。我们报告了成功联合使用氨力农和胰高血糖素治疗一名30岁女性，该女性摄入了3.6克维拉帕米并出现难治性低血压。联合使用这两种药物可能以最小的心肌氧耗增加提供更好的心肌收缩力支持。在这个病例中，氨力农和胰高血糖素联合使用在处理与钙通道阻滞剂过量相关的血流动力学不稳定方面是安全有效的。
