Casl M T, Sabljar-Matovinović M, Kovacević S, Pocanić D, Preden-Kereković V, Jagarinec N
Department of Biochemistry and Biomedicine, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia.
Ann Clin Biochem. 1993 May;30 ( Pt 3):272-7. doi: 10.1177/000456329303000308.
We have evaluated the clinical relevance of monitoring acute phase proteins in severe urinary tract infection. Body temperature, white blood cell count, erythrocyte sedimentation rate, serum amyloid A protein (SAA), C-reactive protein (CRP), alpha-1-antichymotrypsin (ACT) and alpha-1-acid glycoprotein (AGP) were determined daily in sera from 18 treated patients. Two patterns of response could be identified: responders and non-responders whose therapy had to be changed. Mean values for each acute phase protein were calculated daily in both responders and non-responders. Statistical evaluation of the significance between the means for each protein was also performed on a daily basis and showed P < 0.01 for SAA and CRP on day 3, for ACT on day 5, and for AGP on day 6. SAA and CRP appear to be the most reliable markers for antimicrobial therapy monitoring in patients with urinary tract infections.
我们评估了监测急性期蛋白在严重尿路感染中的临床相关性。每天测定18例接受治疗患者血清中的体温、白细胞计数、红细胞沉降率、血清淀粉样蛋白A（SAA）、C反应蛋白（CRP）、α-1-抗糜蛋白酶（ACT）和α-1-酸性糖蛋白（AGP）。可识别出两种反应模式：反应者和必须更改治疗方案的无反应者。每天计算反应者和无反应者中每种急性期蛋白的平均值。每天还对每种蛋白平均值之间的差异进行统计学评估，结果显示第3天SAA和CRP、第5天ACT、第6天AGP的P值均<0.01。SAA和CRP似乎是尿路感染患者抗菌治疗监测中最可靠的标志物。
