免疫化疗可预防裸鼠原位植入组织学完整的肿瘤组织后发生的人结肠癌转移。
Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice.
作者信息
Furukawa T, Kubota T, Watanabe M, Kuo T H, Kase S, Saikawa Y, Tanino H, Teramoto T, Ishibiki K, Kitajima M
机构信息
Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
出版信息
Anticancer Res. 1993 Mar-Apr;13(2):287-91.
A metastatic model of human colon cancer has been previously established using orthotopic onplantation of histologically intact in tissue nude mice. In this study, effects of immunochemotherapy using OK-432, 5-fluorouracil (5-FU) and mitomycin C (MMC) on Col-2-JCK, a human colon cancer xenograft, were evaluated using this model. When 5-FU and MMC were administered without OK-432, liver metastases were not reduced even at maximum tolerated doses of both drugs, although cecal tumor growth was significantly reduced. On the other hand, when combined with OK-432, both 5-FU and MMC reduced liver metastases with synergistic reduction of cecal tumor growth, demonstrating the potential of combining immunotherapy with chemotherapy against metastases.
先前已通过将组织学完整的组织原位移植到裸鼠体内建立了人结肠癌转移模型。在本研究中，使用该模型评估了使用OK-432、5-氟尿嘧啶（5-FU）和丝裂霉素C（MMC）进行免疫化疗对人结肠癌异种移植瘤Col-2-JCK的影响。当不使用OK-432给予5-FU和MMC时，即使两种药物都达到最大耐受剂量，肝转移也没有减少，尽管盲肠肿瘤生长明显减少。另一方面，当与OK-432联合使用时，5-FU和MMC都减少了肝转移，并协同减少了盲肠肿瘤生长，证明了免疫疗法与化疗联合对抗转移的潜力。
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