Intraoral schwannoma. A clinicopathologic and immunohistochemical study of nine cases.

A clinicopathologic review was made of nine cases of benign schwannomas located in the oral cavity. The tumors arose in the vestibule (3 cases), tongue (2 cases), palate (2 cases), floor of the mouth (1 case) and lower lip (1 case). The patients included 5 women and 4 men whose ages ranged from 17 to 75 years (mean: 32.5). No patient developed recurrences. Encapsulated tumors with benign typical histology were evidenced in every case. Positive immunostaining for S-100 protein, Leu 7 antigen, vimentin and glial fibrillary acidic protein (GFAP) supported the schwann cell nature of these tumors.