日本脑炎病毒对原代大鼠脑培养中发育神经元的特异性嗜性。
Specific tropism of Japanese encephalitis virus for developing neurons in primary rat brain culture.
作者信息
Kimura-Kuroda J, Ichikawa M, Ogata A, Nagashima K, Yasui K
机构信息
Department of Microbiology and Immunology, Tokyo Metropolitan Institute for Neuroscience, Japan.
出版信息
Arch Virol. 1993;130(3-4):477-84. doi: 10.1007/BF01309676.
Abstract
Among all the neural cells in fetal rat brain culture developing neurons showed the highest rate of infection by Japanese encephalitis virus (JEV). JEV specifically bound to these cells as measured by immuno-staining. These results indicate that developing neurons are the major target of JEV, and that the initial specific binding of virus to these cells may be one of the reasons for the neurotropism of JEV.
摘要
在胎鼠脑培养物中的所有神经细胞中，发育中的神经元显示出最高的日本脑炎病毒（JEV）感染率。通过免疫染色测定，JEV特异性结合这些细胞。这些结果表明，发育中的神经元是JEV的主要靶标，并且病毒与这些细胞的初始特异性结合可能是JEV嗜神经性的原因之一。
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