Hong W, Tang B L
Membrane Biology Laboratory, National University of Singapore.
Bioessays. 1993 Apr;15(4):231-8. doi: 10.1002/bies.950150403.
Proteins of the exocytotic (secretory) pathway are initially targeted to the endoplasmic reticulum (ER) and then translocated across and/or inserted into the membrane of the ER. During their anterograde transport with the bulk of the membrane flow along the exocytotic pathway, some proteins are selectively retained in various intracellular compartments, while others are sorted to different branches of the pathway. The signals or structural motifs that are involved in these selective targeting processes are being revealed and investigations into the mechanistic nature of these processes are actively underway.
胞吐（分泌）途径的蛋白质最初靶向内质网（ER），然后穿过内质网膜和/或插入内质网膜。在它们随着大部分膜流沿着胞吐途径进行顺向运输的过程中，一些蛋白质被选择性地保留在各种细胞内区室中，而其他蛋白质则被分选到该途径的不同分支。参与这些选择性靶向过程的信号或结构基序正在被揭示，并且对这些过程的机制性质的研究正在积极进行中。
