蛋白质沿胞吐途径的运输。
Protein trafficking along the exocytotic pathway.
作者信息
Hong W, Tang B L
机构信息
Membrane Biology Laboratory, National University of Singapore.
出版信息
Bioessays. 1993 Apr;15(4):231-8. doi: 10.1002/bies.950150403.
Abstract
Proteins of the exocytotic (secretory) pathway are initially targeted to the endoplasmic reticulum (ER) and then translocated across and/or inserted into the membrane of the ER. During their anterograde transport with the bulk of the membrane flow along the exocytotic pathway, some proteins are selectively retained in various intracellular compartments, while others are sorted to different branches of the pathway. The signals or structural motifs that are involved in these selective targeting processes are being revealed and investigations into the mechanistic nature of these processes are actively underway.
摘要
胞吐（分泌）途径的蛋白质最初靶向内质网（ER），然后穿过内质网膜和/或插入内质网膜。在它们随着大部分膜流沿着胞吐途径进行顺向运输的过程中，一些蛋白质被选择性地保留在各种细胞内区室中，而其他蛋白质则被分选到该途径的不同分支。参与这些选择性靶向过程的信号或结构基序正在被揭示，并且对这些过程的机制性质的研究正在积极进行中。
相似文献
1
Protein trafficking along the exocytotic pathway.蛋白质沿胞吐途径的运输。
Bioessays. 1993 Apr;15(4):231-8. doi: 10.1002/bies.950150403.
2
The Golgi apparatus, the plasma membrane, and functional integration.高尔基体、质膜与功能整合
Int Rev Cytol. 1979;58:199-245. doi: 10.1016/s0074-7696(08)61476-x.
3
The trans Golgi network: sorting at the exit site of the Golgi complex.反式高尔基体网络：在高尔基体复合体的出口位点进行分选。
Science. 1986 Oct 24;234(4775):438-43. doi: 10.1126/science.2945253.
4
Protein sorting by selective retention in the endoplasmic reticulum and Golgi stack.通过在内质网和高尔基体中选择性保留进行蛋白质分选。
Cell. 1987 Aug 14;50(4):521-2. doi: 10.1016/0092-8674(87)90024-9.
5
Multiple pathways of exocytosis, endocytosis, and membrane recycling: validation of a Golgi route.胞吐、胞吞和膜循环的多种途径：高尔基体途径的验证
Fed Proc. 1983 May 15;42(8):2407-13.
6
Dual modes of endoplasmic reticulum-to-Golgi transport in dendrites revealed by live-cell imaging.活细胞成像揭示树突内质网到高尔基体转运的双重模式
J Neurosci. 2003 Jul 16;23(15):6188-99. doi: 10.1523/JNEUROSCI.23-15-06188.2003.
8
Membrane traffic between secretory compartments is differentially affected during mitosis.在有丝分裂期间，分泌小室之间的膜转运受到不同程度的影响。
Cell Regul. 1990 Apr;1(5):415-24. doi: 10.1091/mbc.1.5.415.
9
Intracellular protein traffic in lymphocytes: "how do I get THERE from HERE"?淋巴细胞中的细胞内蛋白质运输：“我如何从这里到达那里？”
Immunity. 1999 Oct;11(4):391-8. doi: 10.1016/s1074-7613(00)80114-4.
10
Protein sorting by directed maturation of Golgi compartments.通过高尔基体区室的定向成熟进行蛋白质分选
Science. 1999 Jul 2;285(5424):63-6. doi: 10.1126/science.285.5424.63.
引用本文的文献
1
Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche.Rab8a囊泡在肠道干细胞龛中调节Wnt配体传递和潘氏细胞成熟。
Development. 2015 Jun 15;142(12):2147-62. doi: 10.1242/dev.121046. Epub 2015 May 26.
2
Insights into the mechanisms of membrane curvature and vesicle scission by the small GTPase Sar1 in the early secretory pathway.对早期分泌途径中小GTP酶Sar1介导的膜曲率和囊泡切割机制的见解。
J Mol Biol. 2014 Nov 11;426(22):3811-3826. doi: 10.1016/j.jmb.2014.08.023. Epub 2014 Sep 2.
3
Two isoforms of acid phosphatase secreted by tobacco protoplasts: differential effect of brefeldin A on their secretion.烟草原生质体分泌的两种酸性磷酸酶同工酶：布雷菲德菌素 A 对它们分泌的差异影响。
Plant Cell Rep. 1996 Feb;15(6):409-13. doi: 10.1007/BF00232065.
4
The 'permeome' of the malaria parasite: an overview of the membrane transport proteins of Plasmodium falciparum.疟原虫的“通透组”：恶性疟原虫膜转运蛋白概述
Genome Biol. 2005;6(3):R26. doi: 10.1186/gb-2005-6-3-r26. Epub 2005 Mar 2.
5
Endoplasmic reticulum export sites and Golgi bodies behave as single mobile secretory units in plant cells.内质网输出位点和高尔基体在植物细胞中表现为单个可移动的分泌单位。
Plant Cell. 2004 Jul;16(7):1753-71. doi: 10.1105/tpc.022673. Epub 2004 Jun 18.
6
Portable sulphotransferase domain determines sequence specificity of heparan sulphate 3-O-sulphotransferases.可移动的磺基转移酶结构域决定硫酸乙酰肝素3-O-磺基转移酶的序列特异性。
Biochem J. 2001 Oct 1;359(Pt 1):235-41. doi: 10.1042/0264-6021:3590235.
7
Morphological and functional association of Sec22b/ERS-24 with the pre-Golgi intermediate compartment.Sec22b/ERS-24与高尔基体前中间区室的形态学和功能关联。
Mol Biol Cell. 1999 Feb;10(2):435-53. doi: 10.1091/mbc.10.2.435.
8
A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased during in vitro myogenesis and present in the plasma membrane.一种新型突触囊泡蛋白/囊泡相关膜蛋白同源蛋白（VAMP5）在体外肌生成过程中表达增加，并存在于质膜中。
Mol Biol Cell. 1998 Sep;9(9):2423-37. doi: 10.1091/mbc.9.9.2423.
9
Ceramide transport from endoplasmic reticulum to Golgi apparatus is not vesicle-mediated.神经酰胺从内质网到高尔基体的转运不是由囊泡介导的。
Biochem J. 1998 Aug 1;333 ( Pt 3)(Pt 3):779-86. doi: 10.1042/bj3330779.
10
Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome.内体蛋白，一种新型的突触融合蛋白/VAMP样蛋白，优先与早期内体相关联。
Mol Biol Cell. 1998 Jun;9(6):1549-63. doi: 10.1091/mbc.9.6.1549.
本文引用的文献
1
Molecular cloning, characterization, subcellular localization and dynamics of p23, the mammalian KDEL receptor.哺乳动物KDEL受体p23的分子克隆、特性分析、亚细胞定位及动态变化
J Cell Biol. 1993 Jan;120(2):325-38. doi: 10.1083/jcb.120.2.325.
2
The Golgi apparatus (complex)-(1954-1981)-from artifact to center stage.高尔基体（复合体）-（1954年-1981年）-从人为现象到核心地位。
J Cell Biol. 1981 Dec;91(3 Pt 2):77s-103s. doi: 10.1083/jcb.91.3.77s.
3
Assembly of asparagine-linked oligosaccharides.天冬酰胺连接寡糖的组装
Annu Rev Biochem. 1985;54:631-64. doi: 10.1146/annurev.bi.54.070185.003215.
4
Temperature and energy dependence of secretory protein transport in the exocrine pancreas.外分泌胰腺中分泌蛋白运输的温度和能量依赖性
EMBO J. 1986 Jul;5(7):1477-82. doi: 10.1002/j.1460-2075.1986.tb04385.x.
5
Protein sorting by selective retention in the endoplasmic reticulum and Golgi stack.通过在内质网和高尔基体中选择性保留进行蛋白质分选。
Cell. 1987 Aug 14;50(4):521-2. doi: 10.1016/0092-8674(87)90024-9.
6
The trans Golgi network: sorting at the exit site of the Golgi complex.反式高尔基体网络：在高尔基体复合体的出口位点进行分选。
Science. 1986 Oct 24;234(4775):438-43. doi: 10.1126/science.2945253.
7
Glycosyltransferases. Structure, localization, and control of cell type-specific glycosylation.糖基转移酶。细胞类型特异性糖基化的结构、定位及调控
J Biol Chem. 1989 Oct 25;264(30):17615-8.
8
Morphogenesis of the polarized epithelial cell phenotype.极化上皮细胞表型的形态发生。
Science. 1989 Aug 18;245(4919):718-25. doi: 10.1126/science.2672330.
9
Lysosomal acid phosphatase is transported to lysosomes via the cell surface.溶酶体酸性磷酸酶通过细胞表面被转运至溶酶体。
EMBO J. 1989 Dec 1;8(12):3633-40. doi: 10.1002/j.1460-2075.1989.tb08537.x.
10
Palmitylation of viral membrane glycoproteins takes place after exit from the endoplasmic reticulum.
J Biol Chem. 1989 Jul 25;264(21):12590-5.
Zotero 插件