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反式高尔基体网络:在高尔基体复合体的出口位点进行分选。

The trans Golgi network: sorting at the exit site of the Golgi complex.

作者信息

Griffiths G, Simons K

出版信息

Science. 1986 Oct 24;234(4775):438-43. doi: 10.1126/science.2945253.

Abstract

The Golgi complex is a series of membrane compartments through which proteins destined for the plasma membrane, secretory vesicles, and lysosomes move sequentially. A model is proposed whereby these three different classes of proteins are sorted into different vesicles in the last Golgi compartment, the trans Golgi network. This compartment corresponds to a tubular reticulum on the trans side of the Golgi stack, previously called Golgi endoplasmic reticulum lysosomes (GERL).

摘要

高尔基体复合体是一系列膜性区室, destined for the plasma membrane, secretory vesicles, and lysosomes move sequentially. 提出了一种模型,据此这三类不同的蛋白质在高尔基体的最后一个区室——反式高尔基体网络中被分选到不同的囊泡中。该区室对应于高尔基体堆叠反式侧的管状网状结构,以前称为高尔基体内质网溶酶体(GERL)。 (注:原文中“destined for the plasma membrane, secretory vesicles, and lysosomes move sequentially”部分表述不太准确完整,可能影响理解。)

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