人降钙素基因相关肽（CGRP）8 - 37片段对降钙素基因相关肽（CGRP）和胰淀素胰岛素分泌抑制作用的逆转

Reversal of the inhibitory effects of calcitonin gene-related peptide (CGRP) and amylin on insulin secretion by the 8-37 fragment of human CGRP.

作者信息

Silvestre R A, Salas M, Dégano P, Peiró E, Marco J

机构信息

Hospital Puerta de Hierro, Universidad Autónoma de Madrid, Spain.

出版信息

Biochem Pharmacol. 1993 Jun 9;45(11):2343-7. doi: 10.1016/0006-2952(93)90209-f.

DOI:10.1016/0006-2952(93)90209-f

PMID:8517876

Abstract

The 8-37 fragment of human calcitonin gene-related peptide [(8-37)hCGRP] antagonizes the effects of calcitonin gene-related peptide (CGRP) and amylin in a number of tissues. We have studied the influence of (8-37)hCGRP on the effects of both CGRP and amylin on insulin secretion. In the perfused rat pancreas, homologous CGRP and amylin, at 75 pM, exerted comparable inhibitory effects on the insulin response to 9 mM glucose (ca. 70%; P < 0.025). These effects were antagonized by (8-37)hCGRP (1 microM). Our results suggest that CGRP and amylin act on the B-cell, at least in part, through a common receptor.

摘要

人降钙素基因相关肽的8 - 37片段[（8 - 37）hCGRP]在许多组织中可拮抗降钙素基因相关肽（CGRP）和胰淀素的作用。我们研究了（8 - 37）hCGRP对CGRP和胰淀素两者胰岛素分泌作用的影响。在灌注大鼠胰腺中，75 pM的同源CGRP和胰淀素对9 mM葡萄糖刺激的胰岛素反应产生了相当的抑制作用（约70%；P < 0.025）。这些作用被（8 - 37）hCGRP（1 microM）拮抗。我们的结果表明，CGRP和胰淀素至少部分地通过共同受体作用于B细胞。