Schuerer-Maly C C, Emmenegger U, Ott K, Flogerzi B, Halter F
Gastrointestinal Unit, Inselspital Berne, Switzerland.
J Physiol Pharmacol. 1993 Mar;44(1):23-9.
The involvement of inflammation in peptic ulcer development and healing attracts growing interest. Since lymphokines, in particular interleukin-1 (IL-1), as ubiquitous mediators of inflammation are currently intensively studied in the gastrointestinal tract, we assessed the effect of this cytokine as well as that of a specific IL-1 release inhibitor (IX 207-887 (IX)) on development and healing of experimental gastric ulcers. After a single dose of IL-1, 4 micrograms/kg, i. p., basal acid secretion was almost completely inhibited for 4 hours in conscious chronic gastric fistula rats. In a first study, following induction of a 7 mm wide cryo-ulcer in the gastric corpus, three groups of 24 rats were treated either with a non-acid inhibitory dose of IL-1 (0.4 microgram/kg) or with an antisecretory regimen (4 micrograms/kg) b.i.d. or saline control. Ulcer size did not differ from that of control animals, neither after 24h nor 7 days. Similarly, IX applied daily (20 mg/kg/s.c) from 5 days before ulcer induction and continued thereafter for 15 days had no effect on ulcer development or healing. Despite its anti-inflammatory property IX produced no macroscopically visible damage on the gastric or intestinal mucosa and may therefore offer a higher safety profile within the gastrointestinal tract than conventional non-steroidal anti-inflammatory drugs.
炎症在消化性溃疡的发生和愈合过程中的作用引起了越来越多的关注。由于淋巴因子，特别是白细胞介素-1（IL-1）作为普遍存在的炎症介质目前正在胃肠道中得到深入研究，我们评估了这种细胞因子以及一种特定的IL-1释放抑制剂（IX 207-887（IX））对实验性胃溃疡的发生和愈合的影响。腹腔注射单剂量4微克/千克的IL-1后，清醒的慢性胃瘘大鼠的基础胃酸分泌在4小时内几乎完全受到抑制。在第一项研究中，在胃体部诱导出一个7毫米宽的冷冻溃疡后，将三组24只大鼠分别用非抑酸剂量的IL-1（0.4微克/千克）或抗分泌方案（4微克/千克）每日两次或生理盐水进行对照处理。在24小时和7天后，溃疡大小与对照动物相比均无差异。同样，从溃疡诱导前5天开始每天皮下注射IX（20毫克/千克）并持续15天，对溃疡的发生或愈合没有影响。尽管IX具有抗炎特性，但它在胃或肠黏膜上没有产生肉眼可见的损伤，因此与传统的非甾体抗炎药相比，在胃肠道内可能具有更高的安全性。
