Matthys D, Verhaaren H, Benoit Y, Laureys G, De Naeyer A, Craen M
Department of Paediatrics, University Hospital, Gent, Belgium.
Acta Paediatr. 1993 May;82(5):459-62. doi: 10.1111/j.1651-2227.1993.tb12722.x.
The aim of this study was to document gender difference in aerobic capacity after cure from malignant disease in childhood. We studied 18 males and 17 females aged 11-19 years and 10-18 years, respectively. They had all completed their treatment at least two years previously. Twelve males and 11 females received anthracyclines in comparable doses (range 150-500 mg/m2). Maximal exercise tests were performed on a cycle ergometer. Maximal oxygen consumption (ml/min/kg) was significantly (p < 0.001) lower only in females when compared to their controls. We postulate two causes: girls are smaller than their controls, possibly related to their higher vulnerability to cranial irradiation than boys; and girls were less involved than boys in sports. The influence of anthracycline treatment on aerobic capacity was only observed in males and not in females. This could be related to the higher exercise level in boys than in girls.
本研究的目的是记录儿童恶性疾病治愈后有氧能力的性别差异。我们分别研究了18名年龄在11 - 19岁的男性和17名年龄在10 - 18岁的女性。他们均至少在两年前完成了治疗。12名男性和11名女性接受了剂量相当（范围为150 - 500 mg/m²）的蒽环类药物治疗。在自行车测力计上进行最大运动测试。与对照组相比，仅女性的最大耗氧量（ml/min/kg）显著降低（p < 0.001）。我们推测有两个原因：女孩比她们的对照组身材更小，这可能与她们比男孩更容易受到头颅照射有关；并且女孩比男孩更少参与体育活动。蒽环类药物治疗对有氧能力的影响仅在男性中观察到，而在女性中未观察到。这可能与男孩比女孩更高的运动水平有关。
