Barnes M I, Mitchell C L
Laboratory of Molecular and Integrative Neuroscience, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Brain Res Bull. 1993;31(6):733-6. doi: 10.1016/0361-9230(93)90149-6.
Wet dog shaking elicited by perforant path stimulation is little affected by bilateral injection of colchicine into the dorsal hippocampal formation but virtually eliminated by bilateral injection into the ventral hippocampal formation. Injection of colchicine into either dorsal or ventral hippocampal formation lowers the threshold for eliciting forelimb clonus with rearing. This effect is more pronounced 8 weeks postinjection than 2 weeks postinjection when colchicine is injected in the ventral hippocampal formation. This suggests that inappropriate reactive synaptogenesis and/or neuronal degeneration continues for an extended period after intrahippocampal injection of colchicine, especially in the ventral hippocampal formation.
由穿通路径刺激引发的湿狗样抖动很少受到双侧海马背侧结构注射秋水仙碱的影响，但双侧海马腹侧结构注射秋水仙碱后几乎完全消除。向海马背侧或腹侧结构注射秋水仙碱会降低引发前肢阵挛的阈值。当秋水仙碱注射到海马腹侧结构时，这种效应在注射后8周比注射后2周更明显。这表明海马内注射秋水仙碱后，不适当的反应性突触发生和/或神经元变性会持续较长时间，尤其是在海马腹侧结构中。
