Bridges A B, McNeill G P, Pringle T H, Niblock A, Belch J J
University Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK.
Cardiology. 1993;82(1):7-11. doi: 10.1159/000175847.
Markers suggestive of enhanced free radical (FR) activity have been demonstrated in patients with chest pain and normal coronary angiograms. This may be of pathogenetic importance because FRs impair vascular relaxation and are generated following episodes of myocardial ischaemia/reperfusion. Fifteen patients with angina pectoris, normal coronary angiograms and either a positive exercise tolerance test and/or abnormal dipyridamole thallium tomogram were studied along with 15 age-, sex- and smoking-matched controls. A peripheral venous blood sample was obtained to measure the following FR markers: malondialdehyde, plasma thiols, red blood cell glutathione and superoxide dismutase. No significant differences were detected in the levels of any of the FR markers between either the group of 15 patients with chest pain and normal angiograms or the subgroup with positive exercise tolerance tests when compared to the controls. There is therefore no evidence of enhanced FR activity in patients with chest pain and normal coronary angiograms in peripheral venous blood samples.
在胸痛且冠状动脉造影正常的患者中，已证实存在提示自由基（FR）活性增强的标志物。这可能具有致病学意义，因为自由基会损害血管舒张功能，并且在心肌缺血/再灌注发作后产生。对15例患有心绞痛、冠状动脉造影正常且运动耐量试验阳性和/或双嘧达莫铊心肌断层扫描异常的患者，以及15例年龄、性别和吸烟情况相匹配的对照组进行了研究。采集外周静脉血样本以测量以下自由基标志物：丙二醛、血浆硫醇、红细胞谷胱甘肽和超氧化物歧化酶。与对照组相比，15例胸痛且冠状动脉造影正常的患者组或运动耐量试验阳性的亚组中，任何自由基标志物的水平均未检测到显著差异。因此，在胸痛且冠状动脉造影正常的患者的外周静脉血样本中，没有证据表明自由基活性增强。
