Roguin A, Ben-Arush M W, Dale J
Department of Pediatric Oncology, Rambam Medical Center, Technion Faculty of Medicine, Haifa, Israel.
Pediatr Hematol Oncol. 1995 Sep-Oct;12(5):447-54. doi: 10.3109/08880019509009474.
We retrospectively analyzed all 164 cases of pediatric lymphoma diagnosed in northern Israel during the 18-year period from 1973 to 1990. Our findings generally conformed to those of other studies with regard to annual incidence (24.7/million), age at diagnosis (5 to 9 years for Jewish males, later for others), histology (Hodgkin's disease most commonly), and male predominance. The northern Israeli pediatric lymphoma pattern of incidence is similar to the Asian-African-South American pattern and unlike that of Europe or North America; in Israel, lymphoma rather than brain tumor is the second most common childhood malignancy. The nodular sclerosing variant was the most common histology seen in Hodgkin's lymphoma (especially in females), followed by mixed cellularity. Malignancies are generally more common in Jewish children but lymphomas in particular were seen more often in Arabs (28.7/million), while the Ashkenasi (20.8/million) and Sephardi (21.6/million) Jewish populations had similar incidences. The high rate of consanguineous marriages among Arabs and their lower socioeconomic level may explain the high incidence of lymphomas in this group.
我们回顾性分析了1973年至1990年这18年间在以色列北部诊断出的164例儿童淋巴瘤病例。我们的研究结果在年发病率（24.7/百万）、诊断年龄（犹太男性为5至9岁，其他人群稍晚）、组织学类型（最常见的是霍奇金淋巴瘤）以及男性占主导方面总体上与其他研究一致。以色列北部儿童淋巴瘤的发病模式与亚非南美模式相似，与欧洲或北美模式不同；在以色列，淋巴瘤而非脑肿瘤是第二常见的儿童恶性肿瘤。结节硬化型是霍奇金淋巴瘤中最常见的组织学类型（尤其在女性中），其次是混合细胞型。恶性肿瘤在犹太儿童中通常更为常见，但淋巴瘤在阿拉伯儿童中尤其更为常见（28.7/百万），而阿什肯纳兹犹太人群（20.8/百万）和西班牙裔犹太人群（21.6/百万）的发病率相似。阿拉伯人近亲结婚率高及其较低的社会经济水平可能解释了该群体中淋巴瘤的高发病率。
