通过血清淀粉酶和脂肪酶检测对急性胰腺炎的病因及严重程度进行早期预测。
Early prediction of aetiology and severity of acute pancreatitis by serum amylase and lipase assays.
作者信息
Manes G, Rabitti P G, Laccetti M, Pacelli L, Carraturo I, Uomo G
机构信息
XXI Divisione Medicina Interna Centro Malattie del Pancreas, Ospedale A. Cardarelli, Napoli.
出版信息
Minerva Gastroenterol Dietol. 1995 Sep;41(3):211-5.
OBJECTIVE
To evaluate whether simple pancreatic enzyme assays are useful in the early assessment of aetiology and prognosis of acute pancreatitis.
DESIGN
A retrospective clinical study.
SETTING
Department of Internal Medicine with a Pancreatic Disease Centre.
PATIENTS
The study included 246 patients with acute pancreatitis admitted to our Unit within the first 24 hours from the onset of disease. Amylase and lipase serum levels and lipase/amylase ratio were evaluated.
RESULTS
Serum amylase was higher in patients with necrotizing pancreatitis than oedematous and biliary pancreatitis than alcoholic (p < 0.009 and p < 0.05 respectively), but a high degree of overlap between values was found. No differences were noted in lipase serum levels. Lipase/amylase ratio was not different between patients with alcoholic and nonalcoholic pancreatitis.
CONCLUSIONS
Evaluation of serum amylase and lipase is not useful for assessing aetiology and severity of acute pancreatitis, although amylase may be higher in severe and biliary forms.
目的
评估简单的胰腺酶检测对急性胰腺炎病因及预后的早期评估是否有用。
设计
一项回顾性临床研究。
地点
设有胰腺疾病中心的内科。
患者
本研究纳入了发病后24小时内入住我院的246例急性胰腺炎患者。评估血清淀粉酶和脂肪酶水平以及脂肪酶/淀粉酶比值。
结果
坏死性胰腺炎患者的血清淀粉酶高于水肿性胰腺炎患者，胆源性胰腺炎患者的血清淀粉酶高于酒精性胰腺炎患者（分别为p < 0.009和p < 0.05），但发现数值之间存在高度重叠。血清脂肪酶水平无差异。酒精性和非酒精性胰腺炎患者的脂肪酶/淀粉酶比值无差异。
结论
血清淀粉酶和脂肪酶的评估对急性胰腺炎病因及严重程度的评估无用，尽管在重症和胆源性胰腺炎中淀粉酶可能较高。
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