最初通过细针穿刺（FNA）细胞学检查诊断为霍奇金病的Ki-1阳性间变性大细胞淋巴瘤。

Ki-1-positive anaplastic large cell lymphoma initially diagnosed as Hodgkin's disease by fine needle aspiration (FNA) cytology.

作者信息

Aljajeh I A, Das D K, Krajci D

机构信息

Unit of Histopathology, Farwaniya Hospital, Kuwait.

出版信息

Cytopathology. 1995 Aug;6(4):226-35. doi: 10.1111/j.1365-2303.1995.tb00474.x.

DOI:10.1111/j.1365-2303.1995.tb00474.x

PMID:8520002

Abstract

A 45-year-old male presented with a large mass in the left axilla. FNA cytology was interpreted as Hodgkin's disease (HD), lymphocyte depletion (LD) type, but histopathologic and immunohistochemical examination showed features of Ki-1-positive anaplastic large cell lymphoma. Unrepresentative sampling by the FNA from the tumour periphery resulted in a false impression of dual reactive and neoplastic cell populations, which together with the frequent Reed-Sternberg-like cells led to the initial erroneous impression of HD. Therefore, the cytologic diagnosis of HD, LD should be approached with caution.

摘要

一名45岁男性患者左腋窝出现一个大肿块。细针穿刺抽吸活检（FNA）细胞学检查结果被解释为霍奇金淋巴瘤（HD），淋巴细胞消减型（LD），但组织病理学和免疫组化检查显示为Ki-1阳性间变性大细胞淋巴瘤的特征。FNA从肿瘤周边进行的非代表性采样导致了对双重反应性和肿瘤性细胞群的错误印象，再加上频繁出现的里德-施特恩伯格样细胞，导致了最初对HD的错误诊断。因此，对HD、LD的细胞学诊断应谨慎对待。