Grosso L E, Collins B T, Dunphy C H, Ramos R R
Department of Pathology, Saint Louis University School of Medicine, Missouri, USA.
Diagn Cytopathol. 1998 Jul 1;19(1):66-9. doi: 10.1002/(sici)1097-0339(199807)19:1<66::aid-dc14>3.0.co;2-6.
The diagnosis of Hodgkin's disease by fine-needle aspiration (FNA) can be problematic. A case of Hodgkin's disease, lymphocyte depleted subtype, sample by FNA biopsy is presented. We describe the cytomorphologic features present in this unusual subtype of Hodgkin's disease and discuss the differential diagnosis. Immunohistochemical and morphologic findings of a subsequent biopsy specimen supported the diagnosis. Although FNA is an increasingly used diagnostic modality to evaluate tumors including malignant lymphomas, Hodgkin's disease remains, as in this case, a difficult diagnosis by FNA.
通过细针穿刺（FNA）诊断霍奇金病可能存在问题。本文报告1例经FNA活检取样的淋巴细胞消减型霍奇金病病例。我们描述了这种不常见的霍奇金病亚型中存在的细胞形态学特征，并讨论了鉴别诊断。后续活检标本的免疫组化和形态学结果支持了该诊断。尽管FNA是一种越来越多地用于评估包括恶性淋巴瘤在内的肿瘤的诊断方法，但如本病例所示，霍奇金病通过FNA诊断仍然困难。
