Hirai T, Iwata T, Hirabayashi N, Yamashita Y, Yoshimoto A, Noma K, Toge T
Department of Surgical Oncology, Hiroshima University, Japan.
Surg Today. 1995;25(8):684-9. doi: 10.1007/BF00311483.
The usefulness of a heat sensitivity test which involved performing an ATP assay on endoscopic biopsy materials for predicting the clinical response to hyperthermia was investigated in esophageal cancer patients. Following in vitro heat treatment of FM3A tumor cells, the heat sensitivity detected by ATPA was significantly correlated with that in the colony-forming assay, and the percent inhibition of the ATP level in the tumor cells was correlated with in vivo tumor growth. The heat sensitivity of the biopsy materials evaluated by ATPA correlated well with that of the resected specimens in 18 esophageal cancer patients, while the clinical response to thermal therapy was well predicted by the heat sensitivity of the biopsy materials evaluated by ATPA in seven of the patients. These results indicate that the heat sensitivity test conducted by performing an ATPA on endoscopic biopsy materials could be a useful indicator for predicting the clinical response to thermal therapy.
在食管癌患者中，研究了一种热敏感性测试的实用性，该测试涉及对内镜活检材料进行ATP检测以预测对热疗的临床反应。对FM3A肿瘤细胞进行体外热处理后，通过ATP检测法检测到的热敏感性与集落形成试验中的热敏感性显著相关，并且肿瘤细胞中ATP水平的抑制百分比与体内肿瘤生长相关。在18例食管癌患者中，通过ATP检测法评估的活检材料的热敏感性与切除标本的热敏感性相关性良好，而在7例患者中，通过ATP检测法评估的活检材料的热敏感性可以很好地预测热疗的临床反应。这些结果表明，通过对内镜活检材料进行ATP检测所进行的热敏感性测试可能是预测热疗临床反应的有用指标。
