Hancock D C, O'Reilly N J, Evan G I
Biochemistry of the Cell Nucleus and Peptide Synthesis Laboratories, Imperial Cancer Research Fund, London, UK.
Mol Biotechnol. 1995 Aug;4(1):73-86. doi: 10.1007/BF02907472.
Synthetic peptides play an important role in many areas of biological research. Advances in synthetic chemistry and automation over the past few years have resulted in increasingly reliable and rapid syntheses. As a result, peptides are now frequently employed in immunological studies, structural studies, as enzyme substrates, in ligand/receptor studies, and as probes for a range of molecular interactions. This review describes solid-phase peptide synthesis and the applications of synthetic peptides in molecular biology and biochemistry.
合成肽在生物学研究的许多领域发挥着重要作用。过去几年中，合成化学和自动化技术的进步使得合成过程越来越可靠且迅速。因此，肽现在经常用于免疫学研究、结构研究、作为酶底物、用于配体/受体研究以及作为一系列分子相互作用的探针。本综述描述了固相肽合成以及合成肽在分子生物学和生物化学中的应用。
