Madjar H, Prömpeler H J, Sauerbrei W, Mundinger A, Pfleiderer A
Department of Gynecology and Obstetrics, Albert-Ludwigs University, Freiburg, Germany.
Ultrasound Obstet Gynecol. 1995 Sep;6(3):199-204. doi: 10.1046/j.1469-0705.1995.06030199.x.
Color Doppler allows flow detection in small tumor vessels. Due to the vascularity associated with the growth of malignancies, this method can be used to differentiate between benign and malignant breast lesions. In order to study the typical flow characteristics, we investigated multiple Doppler flow parameters. A UM9 HDI (ATL) was used with a linear transducer L 10-5. The number of tumor vessels and the mean, maximum and total flow velocity were measured in 325 benign and 133 malignant lesions and showed highly significant differences (p < 0.0001). Flow profiles (resistance index and systolic/diastolic frequency ratio) showed a large overlap and did not allow accurate tumor differentiation when mean and minimum values were analyzed. Surprisingly, the maximum resistance index and systolic/diastolic frequency ratio were significantly higher in carcinomas than in benign lesions, but the overlap of the values was wider than the flow velocity measurements. Using the vessel number and the total tumor vascularity, 90% of all lesions could be differentiated. A difficulty that we encountered was that a few cancers have very low flow values and some of the proliferative benign lesions can have increased flow.
彩色多普勒可检测小肿瘤血管中的血流。由于恶性肿瘤生长相关的血管形成，该方法可用于鉴别乳腺良性和恶性病变。为了研究典型的血流特征，我们调查了多个多普勒血流参数。使用配备线性换能器L 10 - 5的UM9 HDI（ATL）。在325个良性病变和133个恶性病变中测量了肿瘤血管数量以及平均、最大和总流速，结果显示存在高度显著差异（p < 0.0001）。血流剖面（阻力指数和收缩期/舒张期频率比）显示有很大重叠，在分析平均值和最小值时无法实现准确的肿瘤鉴别。令人惊讶的是，癌组织中的最大阻力指数和收缩期/舒张期频率比显著高于良性病变，但这些值的重叠程度比流速测量结果更宽。利用血管数量和肿瘤总血管形成情况，90%的病变能够被鉴别。我们遇到的一个困难是，一些癌症的血流值非常低，而一些增殖性良性病变的血流可能增加。
