Butera R J, Clark J W, Canavier C C, Baxter D A, Byrne J H
Dept. of Electrical and Computer Engineering, Rice University, Houston, TX 77251-1892, USA.
J Comput Neurosci. 1995 Mar;2(1):19-44. doi: 10.1007/BF00962706.
In a computational model of the bursting neuron R15, we have implemented proposed mechanisms for the modulation of two ionic currents (IR and ISI) that play key roles in regulating its spontaneous electrical activity. The model was sufficient to simulate a wide range of endogenous activity in the presence of various concentrations of serotonin (5-HT) or dopamine (DA). The model was also sufficient to simulate the responses of the neuron to extrinsic current pulses and the ways in which those responses were altered by 5-HT or DA. The results suggest that the actions of modulatory agents and second messengers on this neuron, and presumably other neurons, cannot be understood on the basis of their direct effects alone. It is also necessary to take into account the indirect effects of these agents on other unmodulated ion channels. These indirect effects occur through the dynamic interactions of voltage-dependent and calcium-dependent processes.
在爆发性神经元R15的计算模型中，我们实现了对两种离子电流（IR和ISI）调节的拟议机制，这两种离子电流在调节其自发电活动中起关键作用。该模型足以在存在各种浓度的血清素（5-HT）或多巴胺（DA）的情况下模拟广泛的内源性活动。该模型也足以模拟神经元对外源电流脉冲的反应以及这些反应被5-HT或DA改变的方式。结果表明，调节因子和第二信使对该神经元以及可能对其他神经元的作用，不能仅基于它们的直接作用来理解。还必须考虑这些因子对其他未调制离子通道的间接作用。这些间接作用通过电压依赖性和钙依赖性过程的动态相互作用而发生。
