杜氏肌营养不良症中的血清肌酸激酶同工酶
Serum creatine kinase isoenzymes in Duchenne muscular dystrophy.
作者信息
Takahashi K, Shutta K, Matsuo B, Takai T, Takao H, Imura H
出版信息
Clin Chim Acta. 1977 Mar 15;75(3):435-42. doi: 10.1016/0009-8981(77)90363-1.
Creatine kinase isoenzymes in sera of 51 patients with Duchenne muscular dystrophy were separated on a micro-column of DEAE Sephadex A-50. MB isoenzyme was detected in the sera of 32 cases (63%). MB percentage of total creatine kinase activity correlated significantly with urinary creatine/creatinine ratio in the early stages of the disease. No close relationship between MB levels and ECG findings was observed. The origin of serum MB in Duchenne dystrophy is discussed.
采用DEAE葡聚糖A - 50微柱对51例杜兴氏肌营养不良患者血清中的肌酸激酶同工酶进行分离。在32例患者（63%）的血清中检测到了MB同工酶。在疾病早期，MB同工酶占总肌酸激酶活性的百分比与尿肌酸/肌酐比值显著相关。未观察到MB水平与心电图表现之间存在密切关系。本文对杜兴氏肌营养不良患者血清中MB同工酶的来源进行了讨论。
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