Silverman L M, Mendell J R, Sahenk Z, Fontana M B
Neurology. 1976 Jun;26(6 PT 1):561-4. doi: 10.1212/wnl.26.6.561.
Study of creatine phosphokinase (CPK) isoenzymes using a quantitative column chromatographic technique showed that there was a significant difference in serum MB isoenzyme activity between patients with Duchenne muscular dystrophy (42 mU per milliter) and those with other kinds of neuromuscular diseases (8 mU per milliter). In the Duchenne patients, the serum MB isoenzyme activity did not correlate with clinical cardiac disease. Furthermore, skeletal muscle damage produced in the rat by aortic ligation and 5-hydroxytryptamine resulted in significant elevations of plasma MB isoenzyme activty. These studies suggest that the serum MB isoenzyme activity in the Duchenne muscular dystrophy patients is probably arising from skeletal, not cardiac muscle and may reflect a distinct pathogenesis from other kinds of neuromuscular disorders.
采用定量柱色谱技术对肌酸磷酸激酶（CPK）同工酶进行的研究表明，杜兴氏肌营养不良症患者（每毫升42毫微单位）与其他类型神经肌肉疾病患者（每毫升8毫微单位）的血清MB同工酶活性存在显著差异。在杜兴氏患者中，血清MB同工酶活性与临床心脏病无关。此外，大鼠因主动脉结扎和5-羟色胺导致的骨骼肌损伤会使血浆MB同工酶活性显著升高。这些研究表明，杜兴氏肌营养不良症患者的血清MB同工酶活性可能源于骨骼肌而非心肌，并且可能反映出与其他类型神经肌肉疾病不同的发病机制。
