Gu Z, Zhu P, Luo H, Zhu X, Zhang G, Wu S
National Research Institute for Family Planning, Beijing, China.
Contraception. 1995 Jul;52(1):57-61. doi: 10.1016/0010-7824(95)00125-t.
The endometrium was studied by morphometry in 34 healthy women before and after one year's use of an IUD releasing levonorgestrel at a rate 20 micrograms/24 hr (LNG-IUD-20). The effect was compared with that of an IUD releasing 2 micrograms levonorgestrel/24 hr (LNG-IUD-2). The appearance of suppressed endometrial proliferative activity and increased inflammatory reaction was similar in the two experimental groups, suggesting that the morphological alterations were independent of the LNG dosage. The result of this study, combined with clinical data, suggests that LNG-IUD-20 could replace LNG-IUD-2 without any additional side effects. The efficacy of LNG-IUD-20 is also likely to last for a longer period than the LNG-IUD-2.
对34名健康女性在使用每日释放20微克左炔诺孕酮的宫内节育器（LNG-IUD-20）一年前后进行子宫内膜形态测量学研究。将其效果与每日释放2微克左炔诺孕酮的宫内节育器（LNG-IUD-2）进行比较。两个实验组中子宫内膜增殖活性受抑制和炎症反应增加的表现相似，表明形态学改变与左炔诺孕酮剂量无关。本研究结果结合临床数据表明，LNG-IUD-20可以替代LNG-IUD-2，且不会产生任何额外副作用。LNG-IUD-20的疗效可能也比LNG-IUD-2持续时间更长。
