Philip G H, Reddy P M, Sridevi G
Department of Zoology, Sri Krishnadevaraya University, Andhra Pradesh, India.
Ecotoxicol Environ Saf. 1995 Jul;31(2):173-8. doi: 10.1006/eesa.1995.1059.
Aspects of carbohydrate metabolism under in vivo conditions were analyzed in functionally different tissues of the freshwater fish, Labeo rohita, exposed to a lethal (LC50/96 hr = 5.24 micrograms liter-1) and sublethal concentration (0.52 micrograms liter-1) of cypermethrin for 4 days. All exposed fish exhibited a hyperglycemic condition. An increase in tissue lactate with a decrease in pyruvate, total carbohydrates, and glycogen contents was noted. Activity of lactate dehydrogenase was elevated, indicating a shift toward anaerobiosis. TCA cycle enzymes, namely succinate dehydrogenase and malate dehydrogenase, were inhibited. In most cases changes were more pronounced during a lethal exposure compared to sublethal exposure period. The data indicate that the fish has adopted a compensatory mechanism to derive energy during pyrethroid toxicosis.
对暴露于氯氰菊酯致死浓度（LC50/96小时 = 5.24微克/升）和亚致死浓度（0.52微克/升）4天的淡水鱼——露斯塔野鲮功能不同的组织中体内碳水化合物代谢的各个方面进行了分析。所有暴露的鱼都呈现高血糖状态。观察到组织乳酸增加，同时丙酮酸、总碳水化合物和糖原含量减少。乳酸脱氢酶的活性升高，表明向无氧代谢转变。三羧酸循环酶，即琥珀酸脱氢酶和苹果酸脱氢酶受到抑制。在大多数情况下，与亚致死暴露期相比，致死暴露期间的变化更为明显。数据表明，鱼类在拟除虫菊酯中毒期间采用了一种补偿机制来获取能量。
