Rosario D J, Woo H H, Parkhouse H, Chapple C R
Department of Urology, Royal Hallamshire Hospital, London, UK.
Eur Urol. 1995;28(1):64-7. doi: 10.1159/000475022.
The aim of this work was to investigate the effects of intravenously administered thyrotropin-releasing hormone (TRH) on the urethral closure pressure in a double-blind, placebo-controlled study.
Sixteen female subjects with either bladder outlet obstruction (BOO) or detrusor underactivity were included in the study. Following randomization, 8 subjects (3 BOO, 5 detrusor underactivity) received 200 micrograms of TRH intravenously, and 8 (4 BOO, 4 detrusor underactivity) received saline (placebo). Standard fluid fill urethral pressure profilometry was performed at baseline and 2, 3, 5, 10, 15, and 20 min following TRH injection, measuring functional profile length (FPL), maximum urethral closure pressure (UCP), and closure pressures at the proximal quarter of the FPL (1/4 UCP) and at the distal quarter of the FPL (3/4 UCP).
Significant reductions were found in both FPL (p = 0.022) and 3/4 UCP (p = 0.014) in the 'active' group as compared with the 'placebo' group.
TRH administration significantly reduces the distal urethral closure pressure. Clarification of the mechanism of action of TRH on the urethra may point the way towards new developments in the management of female voiding dysfunction.
本研究旨在通过一项双盲、安慰剂对照试验，探究静脉注射促甲状腺激素释放激素（TRH）对尿道闭合压的影响。
本研究纳入了16名患有膀胱出口梗阻（BOO）或逼尿肌活动减退的女性受试者。随机分组后，8名受试者（3名BOO，5名逼尿肌活动减退）静脉注射200微克TRH，另外8名（4名BOO，4名逼尿肌活动减退）注射生理盐水（安慰剂）。在基线以及注射TRH后的2、3、5、10、15和20分钟进行标准液体充盈尿道压力测定，测量功能尿道长度（FPL）、最大尿道闭合压（UCP）以及FPL近端四分之一处的闭合压（1/4 UCP）和FPL远端四分之一处的闭合压（3/4 UCP）。
与“安慰剂”组相比，“活性”组的FPL（p = 0.022）和3/4 UCP（p = 0.014）均显著降低。
注射TRH可显著降低尿道远端闭合压。阐明TRH对尿道的作用机制可能为女性排尿功能障碍的治疗带来新进展。
