Bhatia N N, Bergman A
Harbor-UCLA Medical Center, UCLA School of Medicine.
Urology. 1988 Feb;31(2):180-3. doi: 10.1016/0090-4295(88)90052-0.
To study the pathophysiology of urinary urgency frequently reported on administration of thyrotropin releasing hormone (TRH), simultaneous urethrocystometry was performed in 10 women before and after administration of 500 micrograms of TRH. Nine women in the control group received normal saline in place of TRH. The TRH group demonstrated a significant drop in urethral closure pressure (p less than 0.01) within two minutes after TRH injection. Eight women complained of urinary urgency during the interval of observed drop in urethral closure pressure. No significant changes were seen in true detrusor pressure in both the TRH and in the control groups. The close association of drop in urethral pressure and urinary urgency suggests the presence of a motor component to this either centrally or peripherally mediated urinary urgency following TRH administration.
为研究促甲状腺激素释放激素（TRH）给药后频繁报告的尿急的病理生理学，对10名女性在注射500微克TRH前后同时进行了尿道膀胱测压。对照组的9名女性接受生理盐水代替TRH。TRH组在注射TRH后两分钟内尿道闭合压显著下降（p<0.01）。8名女性在观察到尿道闭合压下降期间抱怨尿急。TRH组和对照组的逼尿肌真实压力均无显著变化。尿道压力下降与尿急的密切关联表明，TRH给药后这种由中枢或外周介导的尿急存在运动成分。
