Ouyahya F, Bacq Y, Schellenberg F, Metman E H, Weill J
Service d'Hépato-Gastroentérologie, Hôpital Trousseau, Tours.
Gastroenterol Clin Biol. 1995 Aug-Sep;19(8-9):698-702.
Carbohydrate-deficient transferrin has been proposed as a marker of alcohol consumption. The aim of this study was to evaluate the accuracy of the carbohydrate-deficient transferrin serum level, measured by ion exchange chromatography followed by radioimmunoassay (Kit CDTect), for the diagnosis of excessive alcohol intake in patients with liver diseases. Ninety-four patients (68 men, 26 women, age 21-71 years), 42 with alcoholic liver diseases and 52 with non-alcoholic liver diseases, were studied. Twenty-six patients consumed > or = 40 g alcohol per day (mean alcohol intake: 84 +/- 52 g per day) and were considered to be excessive drinkers.
The sensitivity of carbohydrate-deficient transferrin for the diagnosis of excessive alcohol intake was 35%, and the specificity was 91%. By pairing carbohydrate-deficient transferrin with other markers of alcohol consumption, the sensitivity of the association of carbohydrate-deficient transferrin and gammaglutamyl transpeptidase was 96%, and the specificity was 59%.
In patients with liver diseases, carbohydrate-deficient transferrin is a specific marker of excessive alcohol intake but a lack of sensitivity may limit its use.
缺糖转铁蛋白已被提议作为酒精摄入的标志物。本研究的目的是评估采用离子交换色谱法继以放射免疫测定法（试剂盒CDTect）测定的缺糖转铁蛋白血清水平对诊断肝病患者酒精摄入过量的准确性。对94例患者（68例男性，26例女性，年龄21 - 71岁）进行了研究，其中42例患有酒精性肝病，52例患有非酒精性肝病。26例患者每天饮酒≥40克（平均酒精摄入量：每天84±52克），被视为过度饮酒者。
缺糖转铁蛋白诊断酒精摄入过量的敏感性为35%，特异性为91%。将缺糖转铁蛋白与其他酒精摄入标志物相结合，缺糖转铁蛋白与γ-谷氨酰转肽酶联合检测的敏感性为96%，特异性为59%。
在肝病患者中，缺糖转铁蛋白是酒精摄入过量的特异性标志物，但敏感性不足可能限制其应用。
