Dvorak D W, Abbas G, Ali T, Stevenson S, Welling D B
Department of Otolaryngology, Ohio State University, Columbus 43210, USA.
Laryngoscope. 1995 Dec;105(12 Pt 1):1300-4. doi: 10.1288/00005537-199512000-00007.
Chronic tympanic membrane (TM) perforation is a common problem worldwide. Recent reports have shown epidermal growth factor (EGF) to stimulate healing in approximately 80% of chronic TM perforations in chinchillas when applied in three doses over 1 week. The objective of this controlled study is to evaluate the efficacy of long-term EGF in the closure of TM perforations. Chronic chinchilla TM perforations were treated with EGF for up to 6 weeks. One hundred percent (17 of 17) of treatment group perforations completely healed. However, two new findings with this long dosing scheme were reperforation on long-term follow-up and three TMs with cholesteatomas. It is likely that reperforation was due to a progressive thinning seen with prolonged EGF application. Long-term EGF use is not recommended for the treatment of TM perforations because of possible wound healing impairment and possible cholesteatoma induction.
慢性鼓膜穿孔是全球范围内的常见问题。最近的报告显示，当在1周内分三次给药时，表皮生长因子（EGF）可刺激约80%的龙猫慢性鼓膜穿孔愈合。这项对照研究的目的是评估长期使用EGF对鼓膜穿孔闭合的疗效。慢性龙猫鼓膜穿孔用EGF治疗长达6周。治疗组穿孔的100%（17个中的17个）完全愈合。然而，这种长期给药方案有两个新发现，即长期随访时的再次穿孔和三个出现胆脂瘤的鼓膜。再次穿孔可能是由于长期应用EGF导致鼓膜逐渐变薄。由于可能损害伤口愈合和可能诱发胆脂瘤，不建议长期使用EGF治疗鼓膜穿孔。
