Yiwu Central Hospital, Department of Otorhinolaryngology, Yiwu, China.
Braz J Otorhinolaryngol. 2021 Jan-Feb;87(1):53-58. doi: 10.1016/j.bjorl.2019.06.011. Epub 2019 Jul 27.
Traumatic tympanic membrane perforations tend to heal spontaneously. However, in this study, several perforations exhibited abnormal healing, where the morphology of healing tympanic membranes differed from that of non-perforated tympanic membranes. Pseudo-healing of the tympanic membrane was characterized by the accumulation of thickened tissue in the perforated area.
The purpose of this study was to evaluate the utility of epidermal growth factor in cases showing pseudo-healing of traumatic tympanic membrane perforations.
A total of 26 traumatic tympanic membrane perforations showing pseudo-healing were included in this study. In all cases, tissue that accumulated in the perforated area was removed, which subsequently caused a new perforation to form. An epidermal growth factor solution was applied to the tympanic membrane once daily to keep the tympanic membrane moist. Closure rates and times were evaluated at 6 months.
During the 6 months follow-up period, two patients were lost. Of the remaining 24 patients, the closure rate was 100% (24/24) and the closure time was 6.1 ± 2.3 days (range: 3-12 days). The morphology of the healed tympanic membrane was not significantly different from that of the remnant tympanic membrane.
Pseudo-healing of traumatic tympanic membrane perforations affects sound conduction. This can be associated with various symptoms, including tinnitus, aural fullness, and ear discomfort. The excision of excessive epithelial tissue and topical application of epidermal growth factor can correct the pseudo-healing of traumatic tympanic membrane perforations.
外伤性鼓膜穿孔往往会自行愈合。然而，在本研究中，一些穿孔表现出异常愈合，即愈合鼓膜的形态与未穿孔鼓膜不同。鼓膜的假性愈合表现为穿孔区域内增厚组织的积聚。
本研究旨在评估表皮生长因子在外伤性鼓膜穿孔假性愈合中的应用价值。
本研究共纳入 26 例外伤性鼓膜穿孔假性愈合患者。所有患者均切除穿孔区积聚的组织，随后形成新的穿孔。每日一次向鼓膜表面滴注表皮生长因子溶液，保持鼓膜湿润。在 6 个月时评估愈合率和愈合时间。
在 6 个月的随访期间，有 2 例患者失访。在其余 24 例患者中，愈合率为 100%（24/24），愈合时间为 6.1±2.3 天（范围：3-12 天）。愈合鼓膜的形态与剩余鼓膜无明显差异。
外伤性鼓膜穿孔的假性愈合会影响声音传导。这可能与各种症状有关，包括耳鸣、耳闷和耳部不适。切除过多的上皮组织和局部应用表皮生长因子可以纠正外伤性鼓膜穿孔的假性愈合。
