Evans B J, Busby A, Jeanes R, Wilkins A J
Institute of Optometry, London, UK.
Ophthalmic Physiol Opt. 1995 Sep;15(5):481-7. doi: 10.1046/j.1475-1313.1995.9500063j.x.
People who report visual perceptual distortions, typically when reading, that are alleviated by using coloured filters are described as suffering from 'Meares-Irlen Syndrome'. A recent double-masked placebo-controlled trial showed that this condition cannot be solely explained as a placebo effect and that the beneficial filter is idiosyncratic and sometimes needs to be highly specific. Several mechanisms have been suggested for Meares-Irlen Syndrome including ocular motor (binocular and accommodative) anomalies, a sensitivity to patterned stimuli (pattern glare), and a deficit of the transient visual sub-system. We investigated these hypotheses by comparing 16 children, who reported the symptoms described above and who showed a sustained benefit from coloured filters, with 25 control children who came from the same school and were matched for age, reading performance and intelligence. The 'Meares-Irlen Syndrome' group had slightly, but significantly, reduced vergence and accommodative amplitudes and stereo-acuity; they also demonstrated significantly more pattern glare. The two groups did not differ significantly in their visual acuities, refractive error, dissociated or associated heterophoria, AC/A ratio, or ability to perceive 20 Hz flicker. It appears that certain ocular motor factors are correlates of Meares-Irlen Syndrome, rather than the primary underlying cause of the symptoms. The results support the hypothesis that pattern glare may be involved in the mechanism of Meares-Irlen Syndrome.
那些报告存在视觉感知扭曲（通常在阅读时出现）且使用彩色滤光片后症状得到缓解的人被描述为患有“米尔斯-厄伦综合征”。最近一项双盲安慰剂对照试验表明，这种情况不能仅仅解释为安慰剂效应，而且有益的滤光片是因人而异的，有时需要非常特定。对于米尔斯-厄伦综合征，已经提出了几种机制，包括眼动（双眼和调节）异常、对图案刺激的敏感性（图案眩光）以及瞬态视觉子系统的缺陷。我们通过比较16名报告上述症状且从彩色滤光片中持续受益的儿童与25名来自同一学校、年龄、阅读表现和智力相匹配的对照儿童，对这些假设进行了研究。“米尔斯-厄伦综合征”组的聚散和调节幅度以及立体视敏度略有但显著降低；他们也表现出明显更多的图案眩光。两组在视力、屈光不正、分离或联合性隐斜视、AC/A比率或感知20赫兹闪烁的能力方面没有显著差异。似乎某些眼动因素是米尔斯-厄伦综合征的相关因素，而不是症状的主要潜在原因。结果支持图案眩光可能参与米尔斯-厄伦综合征发病机制的假设。
