• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

丘脑切开术和左旋多巴疗法对帕金森病患者言语的影响。

Effect of thalamotomy and levodopa therapy on the speech of Parkinson patients.

作者信息

Quaglieri C E, Celesia G G

出版信息

Eur Neurol. 1977;15(1):34-9. doi: 10.1159/000114786.

DOI:10.1159/000114786
PMID:852463
Abstract

The speech of three groups of Parkinson patients--nonsurgical, postunilateral and postbilateral thalamotomy--was evaluated. Dysarthria, bulbar motility and pyramidal tract indexes were determined for each patient. There was a statistically significant greater impairment in dysarthria and pyramidal tract indexes of patients with thalamotomy. L-Dopa and carbidopa therapy failed to significantly improve speech in any group.

摘要

对三组帕金森病患者——非手术组、单侧丘脑切开术后组和双侧丘脑切开术后组——的言语能力进行了评估。测定了每位患者的构音障碍、延髓运动功能和锥体束指数。丘脑切开术患者的构音障碍和锥体束指数受损程度在统计学上显著更高。左旋多巴和卡比多巴治疗未能使任何一组患者的言语能力得到显著改善。

相似文献

1
Effect of thalamotomy and levodopa therapy on the speech of Parkinson patients.丘脑切开术和左旋多巴疗法对帕金森病患者言语的影响。
Eur Neurol. 1977;15(1):34-9. doi: 10.1159/000114786.
2
The influence of previous stereotactic thalamotomy on l-dopa therapy in Parkinson's disease.
Proc Aust Assoc Neurol. 1976;13:55-60.
3
Management of parkinson's disease--combined therapy with levodopa and thalamotomy.帕金森病的治疗——左旋多巴与丘脑切开术联合治疗
West J Med. 1975 Jan;122(1):1-6.
4
L-dopa therapy and stereotaxic thalamotomy for parkinsonism.左旋多巴疗法和立体定向丘脑切开术治疗帕金森病
Confin Neurol. 1975;37(1-3):259-64. doi: 10.1159/000102753.
5
Stereotactic ventrolateralis thalamotomy for medically refractory tremor in post-levodopa era Parkinson's disease patients.立体定向丘脑腹外侧核毁损术治疗左旋多巴时代帕金森病患者药物难治性震颤
J Neurosurg. 1991 Nov;75(5):723-30. doi: 10.3171/jns.1991.75.5.0723.
6
Proceedings: Late results of thalamotomy in Parkinsonism with and without the influence of levodopa.
Acta Neurochir (Wien). 1975;31(3-4):260.
7
Initiating levodopa/carbidopa therapy with and without entacapone in early Parkinson disease: the STRIDE-PD study.早期帕金森病中应用和不应用恩他卡朋的左旋多巴/卡比多巴治疗:STRIDE-PD 研究。
Ann Neurol. 2010 Jul;68(1):18-27. doi: 10.1002/ana.22060.
8
Long-term follow-up results of bilateral thalamotomy for parkinsonism.帕金森病双侧丘脑切开术的长期随访结果
Appl Neurophysiol. 1976;39(3-4):257-60. doi: 10.1159/000102501.
9
Parkinson's disease: new treatments.帕金森病:新疗法
Compr Ther. 1981 Apr;7(4):38-44.
10
Gastroretentive carbidopa/levodopa, DM-1992, for the treatment of advanced Parkinson's disease.胃滞留型卡比多巴/左旋多巴(DM-1992)治疗晚期帕金森病。
Mov Disord. 2015 Aug;30(9):1222-8. doi: 10.1002/mds.26219. Epub 2015 Apr 2.

引用本文的文献

1
Effects of different side motor impairments at early onset on voice acoustic performance in patients with Parkinson's disease.帕金森病患者早期不同侧运动障碍对嗓音声学表现的影响。
Clin Park Relat Disord. 2025 Oct 22;13:100398. doi: 10.1016/j.prdoa.2025.100398. eCollection 2025.
2
Digital speech biomarkers can measure acute effects of levodopa in Parkinson's disease.数字语音生物标志物可测量左旋多巴对帕金森病的急性影响。
NPJ Parkinsons Dis. 2025 Jul 1;11(1):184. doi: 10.1038/s41531-025-01045-5.
3
Dysarthria in individuals with Parkinson's disease: a protocol for a binational, cross-sectional, case-controlled study in French and European Portuguese (FraLusoPark).
帕金森病患者的构音障碍:一项法语和欧洲葡萄牙语双语横断面病例对照研究方案(FraLusoPark)。
BMJ Open. 2016 Nov 17;6(11):e012885. doi: 10.1136/bmjopen-2016-012885.
4
Dopaminergic therapy in aphasia.失语症的多巴胺能治疗
Aphasiology. 2012 Feb;28(2):155-170. doi: 10.1080/02687038.2013.802286.
5
Evaluation of speech impairment in early stages of Parkinson's disease: a prospective study with the role of pharmacotherapy.帕金森病早期言语障碍评估:一项有药物治疗作用的前瞻性研究。
J Neural Transm (Vienna). 2013 Feb;120(2):319-29. doi: 10.1007/s00702-012-0853-4. Epub 2012 Jul 8.
6
Acoustic analysis in the differentiation of Parkinson's disease and major depression.帕金森病与重度抑郁症鉴别诊断中的声学分析
J Psycholinguist Res. 1992 Sep;21(5):383-9. doi: 10.1007/BF01067922.