Chen Chi-Lin, Lin Ching-Huang, Chen Kai-Li, Su Chen-San
Department of Speech and Language Therapy, Chung Hwa Medical University, No.89, Wenhua 1st St., Rende Dist., Tainan City 71703, Taiwan.
Section of Neurology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Clin Park Relat Disord. 2025 Oct 22;13:100398. doi: 10.1016/j.prdoa.2025.100398. eCollection 2025.
This study aimed to explore the effects of motor impairments on different sides of the body at early onset in relation to voice acoustic performance in patients with Parkinson's disease.
Participants were classified based on which side (left or right) experienced motor impairments first, as well as the stage (early or late) of the disease. Hoehn-Yahr stages one and two were categorized as early-stage, while stages three and four were categorized as late-stage. Participants were divided into four groups: Group A, left-side early-stage conditions; Group B, left-side late-stage conditions; Group C, right-side early-stage conditions; Group D, right-side late-stage conditions. Participants performed three recording tasks that involved sustained phonation of the vowels/a/,/i/, and/u/. The study analyzed four acoustic parameters: Maximum Phonation Time (MPT), jitter, shimmer, and vF0.
An Analysis of Variance revealed that for the acoustic parameters of /a/vF0 and /a/jitter, Group B performed significantly worse than Group A ( < 0.05). No significant differences were found in the other acoustic parameters or in MPT voice performance across the four groups.
The side of motor impairments at early onset is correlated with the severity of voice disorders. Notably, when impairments occur on the left side, the resulting voice disorders become more pronounced as the disease progresses.
本研究旨在探讨帕金森病患者早期身体不同侧的运动障碍与嗓音声学表现之间的关系。
参与者根据首先出现运动障碍的一侧（左侧或右侧）以及疾病阶段（早期或晚期）进行分类。霍恩-亚尔分级的1期和2期被归类为早期，而3期和4期被归类为晚期。参与者被分为四组：A组，左侧早期情况；B组，左侧晚期情况；C组，右侧早期情况；D组，右侧晚期情况。参与者进行了三项录音任务，包括持续发元音/a/、/i/和/u/。研究分析了四个声学参数：最长发声时间（MPT）、抖动、闪烁和嗓音基频（vF0）。
方差分析显示，对于/a/的vF0和/a/的抖动这两个声学参数，B组的表现明显比A组差（<0.05）。在其他声学参数或四组的MPT嗓音表现方面未发现显著差异。
早期运动障碍的一侧与嗓音障碍的严重程度相关。值得注意的是，当左侧出现障碍时，随着疾病进展，由此导致的嗓音障碍会变得更加明显。
