Sant'Ambrogio F B, Anderson J W, Kuna S T, Sant'Ambrogio G
Dept. of Physiology and Biophysics, University of Texas, Galveston 77555-0641, USA.
Respir Physiol. 1995 Jul;101(1):31-9. doi: 10.1016/0034-5687(95)00007-z.
The effects of aerosolizing distilled water and isosmolal dextrose in the isolated larynx on the activity of pressure-responsive receptors and laryngeal muscles were studied in anesthetized dogs. Following water aerosolization, the mean discharge of pressure-responsive laryngeal mechanoreceptors during upper airway breathing and occlusion was 151% and 138% respectively of that present after saline aerosolization. During delivery of water aerosol, the peak activity of the posterior cricoarytenoid muscle increased to 229 +/- 56% of control; no effects were present on the thyroarytenoid muscle activity. Saline or isosmolal dextrose aerosols did not have any effect on the activity of either muscle. The reflex increase in posterior cricoarytenoid muscle activity due to laryngeal negative pressure was enhanced (163%) when the negative pressure challenge was repeated following distilled water aerosol. These results suggest that alteration in laryngeal surface liquid composition modifies the response of pressure-responsive laryngeal receptors and thereby the reflex activation of airway patency maintaining muscles.
在麻醉犬中，研究了雾化蒸馏水和等渗葡萄糖对离体喉部压力感受器和喉部肌肉活动的影响。雾化水后，在上呼吸道呼吸和阻塞期间，压力反应性喉部机械感受器的平均放电分别为雾化盐水后放电的151%和138%。在雾化水期间，环杓后肌的峰值活动增加到对照的229±56%；对甲杓肌活动无影响。盐水或等渗葡萄糖气雾剂对任一肌肉的活动均无影响。当在雾化蒸馏水后重复负压刺激时，由于喉部负压导致的环杓后肌活动的反射性增加增强（163%）。这些结果表明，喉部表面液体成分的改变会改变压力反应性喉部感受器的反应，从而改变维持气道通畅肌肉的反射性激活。
