Breuer-Katschinski B D, Armstrong D, Goebell H, Arnold R, Classen M, Fischer M, Blum A L
Division of Gastroenterology, University of Essen, Germany.
Z Gastroenterol. 1995 Sep;33(9):509-12.
This study reports the influence of smoking on the two-year relapse rate of duodenal ulcers under treatment with ranitidine. 1899 patients with a healed duodenal ulcer received 150 mg ranitidine daily for one year, 1671 patients for two years. During this time period 23.4% of smokers relapsed compared with 26.3% of ex-smokers and 18.0% of non-smokers. The difference between smokers and ex-smokers versus non-smokers was statistically significant. There were significantly fewer relapses among smokers who stopped smoking (14.2%) compared with smokers who continued to smoke (25.2%) during maintenance treatment. These results show that continued and past smoking significantly increase the two-year relapse rate of duodenal ulcers during maintenance treatment with ranitidine.
本研究报告了吸烟对雷尼替丁治疗十二指肠溃疡两年复发率的影响。1899例十二指肠溃疡愈合患者接受每日150毫克雷尼替丁治疗一年，1671例患者治疗两年。在此期间，23.4%的吸烟者复发，相比之下，戒烟者的复发率为26.3%，非吸烟者为18.0%。吸烟者和戒烟者与非吸烟者之间的差异具有统计学意义。在维持治疗期间，戒烟的吸烟者（14.2%）复发的人数明显少于继续吸烟的吸烟者（25.2%）。这些结果表明持续吸烟和既往吸烟显著增加了雷尼替丁维持治疗期间十二指肠溃疡的两年复发率。
