Fulton M K, Kramer G, Moeller F G, Chae Y, Isbell P G, Petty F
Chemical Addiction Program, VA Medical Center, Dallas, TX, USA.
Am J Psychiatry. 1995 Dec;152(12):1819-20. doi: 10.1176/ajp.152.12.1819.
To explore dopaminergic mechanisms in alcohol dependence, the authors measured plasma homovanillic acid (HVA) in recently detoxified alcohol-dependent men.
Plasma HVA was measured in 83 male patients with a diagnosis of alcohol dependence who had maintained documented abstinence for at least 3 weeks and in 69 healthy male comparison subjects.
The alcoholic patients as a group had significantly lower levels of plasma HVA than the comparison subjects. This difference was not influenced by any other measured covariate, including a family history of alcohol dependence.
These results imply that factors such as alcohol dependence should be taken into account in future studies of plasma HVA.
为探究酒精依赖中的多巴胺能机制，作者测量了近期戒酒的酒精依赖男性患者的血浆高香草酸（HVA）水平。
对83名诊断为酒精依赖且已持续至少3周记录在案戒酒的男性患者以及69名健康男性对照者测量其血浆HVA水平。
酒精依赖患者组的血浆HVA水平显著低于对照者。这种差异不受任何其他测量的协变量影响，包括酒精依赖家族史。
这些结果表明，在未来血浆HVA的研究中应考虑酒精依赖等因素。
