Théret L, Germain M L, Burde A
Centre régional de Pharmacovigilance (Pr H. Choisy), CHU, Hôpital de la Maison-Blanche, Reims.
Ann Med Psychol (Paris). 1995 Aug-Sep;153(7):474-7.
The authors report three cases--one of them lethal--of intestinal occlusion among 30 patients treated with clozapine between 1991 and 1994 in Châlons-sur-Marne Psychiatric Hospital. The responsibility of clozapine seems to be linked with its potent anticholinergic property. The attention of prescriptors is necessary and the monitoring of the drug should not be limited to the hematologic aspect.
作者报告了1991年至1994年在马恩河畔沙隆精神病院接受氯氮平治疗的30名患者中有3例肠梗阻病例，其中1例致死。氯氮平的责任似乎与其强大的抗胆碱能特性有关。开处方者必须予以关注，并且对该药物的监测不应仅限于血液学方面。
