一名61岁难治性精神分裂症女性使用氯氮平后发生食管炎

Esophagitis after Clozapine Use in a 61-Year-Old Woman with Refractory Schizophrenia.

作者信息

Ma Sung Min, Lim Junghyun, Jiang Chunsu, Luca Luminita

机构信息

Department of Psychiatry and Behavioral Sciences, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA.

Department of Medicine, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA.

出版信息

Case Rep Psychiatry. 2022 Jun 3;2022:7033038. doi: 10.1155/2022/7033038. eCollection 2022.

DOI:10.1155/2022/7033038

PMID:35693728

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9187460/

Abstract

Clozapine-induced esophagitis has been rarely reported. We herein report a case of a 61-year-old woman with schizophrenia who developed hematemesis, fever, and tachycardia after the initiation of clozapine. An esophagogastroduodenoscopy showed esophageal mucosal ulcerations. Her gastrointestinal symptoms resolved with pantoprazole, allowing continuation of her clozapine treatment. We report here an unusual association of severe esophagitis with clozapine use.

摘要

氯氮平诱发的食管炎鲜有报道。我们在此报告一例61岁的精神分裂症女性患者，在开始使用氯氮平后出现呕血、发热和心动过速。食管胃十二指肠镜检查显示食管黏膜溃疡。她的胃肠道症状通过泮托拉唑治疗得以缓解，从而能够继续使用氯氮平治疗。我们在此报告氯氮平使用与严重食管炎之间一种不寻常的关联。