Pott F
Medizinisches Institut für Umwelthygiene, Heinrich-Heine University, Düsseldorf, Germany.
Ann Occup Hyg. 1995 Oct;39(5):771-9. doi: 10.1016/0003-4878(95)00055-j.
The general experimental design of intraperitoneal (i.p.) carcinogenicity studies with inorganic fibres in rats is described. In a current study, in addition to glass microfibres, size-separated fine respirable fractions of commercial insulation wools (MMVF-11 and MMVF-21) also induced mesotheliomas after i.p. injection of 0.4 x 10(9) fibres. These fibre samples were also tested in inhalation studies. A special glass fibre type (B-01), which is of interest because of its low biodurability, induced tumours with 25- and 50-fold higher doses. The i.p. model has been proved to be much more specific and sensitive for testing the carcinogenicity of inorganic fibres than the inhalation model. Objections to this conclusion are cited and discussed with alternative arguments.
描述了大鼠腹腔内（i.p.）无机纤维致癌性研究的一般实验设计。在当前一项研究中，除了玻璃微纤维外，商业绝缘棉（MMVF - 11和MMVF - 21）经尺寸分离的可吸入细颗粒部分在腹腔注射0.4×10⁹根纤维后也诱发了间皮瘤。这些纤维样本也在吸入研究中进行了测试。一种特殊类型的玻璃纤维（B - 01）因其生物耐久性低而备受关注，它诱发肿瘤所需的剂量高出25至50倍。已证明腹腔内模型在测试无机纤维致癌性方面比吸入模型更具特异性和敏感性。文中引用了对这一结论的反对意见，并通过其他论据进行了讨论。
