Zakraoui H, Ben Salah A, Ftaiti A, Marrakchi H, Zaatour A, Zaafouri B, Ahmadi Z, Garraoui A, Ben Osman A, Dellagi K
Laboratoire d'Epidémiologie et d'Ecologie Parasitaire (LEEP), Institut Pasteur de Tunis.
Ann Dermatol Venereol. 1995;122(6-7):405-7.
The evolution of zoonotic cutaneous leishmaniasis (ZCL) caused by L. major, was usually described with crosssectional studies of patients under anti-leishmanial drugs. This work aimed to describe the clinical and parasitological status by a follow-up study of patients with ZCL and treated with a placebo.
In 1992, 58 patients with unique lesion of ZCL confirmed parasitologically and treated with vaseline twice a day for 15 days were followed in days 0, 15, 45 and 105. During every visit we have performed a clinical description of the lesion, a direct smear and a culture on NNN medium.
81 p. 100 of the lesions were ulcerated in day 0. A rapid clinical healing was noticed in 6.9 p. 100 of patients and the lesion remained active in 25.9 p. 100 of cases until day 105. Direct smears became negative among 56.4 p. 71 p. 100 and 92.3 p. 100 in days 15, 45 and 105 respectively.
The ulcer was the most frequent sign during the diagnosis. The rapid conversion of positive parasitological tests suggest that the diagnosis of ZCL in endemic zones should be based mainly on clinical criteria.
由硕大利什曼原虫引起的人畜共患皮肤利什曼病（ZCL）的演变，通常是通过对抗利什曼病药物治疗患者的横断面研究来描述的。这项工作旨在通过对接受安慰剂治疗的ZCL患者进行随访研究，来描述其临床和寄生虫学状况。
1992年，对58例经寄生虫学确诊为单一ZCL病灶且每天两次用凡士林治疗15天的患者，在第0、15、45和105天进行随访。每次随访时，我们都对病灶进行了临床描述、直接涂片和在NNN培养基上进行培养。
在第0天，81%的病灶出现溃疡。6.9%的患者出现快速临床愈合，25.9%的病例病灶直至第105天仍处于活动状态。直接涂片分别在第15、45和105天，71%、92.3%和56.4%的患者中转为阴性。
溃疡是诊断期间最常见的体征。寄生虫学检测结果快速转阴表明，在流行地区ZCL的诊断应主要基于临床标准。
