口服牛乳铁蛋白可抑制喂食牛奶的小鼠体内的细菌移位。
Orally administered bovine lactoferrin inhibits bacterial translocation in mice fed bovine milk.
作者信息
Teraguchi S, Shin K, Ogata T, Kingaku M, Kaino A, Miyauchi H, Fukuwatari Y, Shimamura S
机构信息
Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd., Kanagawa, Japan.
出版信息
Appl Environ Microbiol. 1995 Nov;61(11):4131-4. doi: 10.1128/aem.61.11.4131-4134.1995.
Abstract
Feeding of bovine milk to mice induced a high incidence of bacterial translocation from the intestines to the mesenteric lymph nodes, and the bacteria involved were mainly members of the family Enterobacteriaceae. Supplementation of the milk diet with bovine lactoferrin or a pepsin-generated hydrolysate of bovine lactoferrin resulted in significant suppression of bacterial translocation. Our findings suggest that this ability of lactoferrin to inhibit bacterial translocation may be due to its suppression of bacterial overgrowth in the guts of milk-fed mice.
摘要
给小鼠喂食牛乳会导致细菌从肠道转移至肠系膜淋巴结的发生率很高，且所涉及的细菌主要是肠杆菌科的成员。在牛奶饮食中补充牛乳铁蛋白或牛乳铁蛋白的胃蛋白酶水解产物可显著抑制细菌转移。我们的研究结果表明，乳铁蛋白抑制细菌转移的这种能力可能是由于其抑制了喂食牛奶小鼠肠道中的细菌过度生长。
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