Lyons T P, Muza S R, Rock P B, Cymerman A
Altitude Physiology and Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760, USA.
Aviat Space Environ Med. 1995 Oct;66(10):957-62.
Acclimatization to high altitude appears to prevent acute mountain sickness (AMS), as evidenced by a decline in AMS symptoms as acclimatization progresses.
We hypothesized that partial retention of acclimatization would attenuate the incidence and/or severity of AMS upon reinduction to altitude.
To test this hypothesis 6 male lowlanders returned to sea level after the acclimatizing of the 16 d at 4300 m (HA). After 8 d at sea level (PA), they were reexposed to 4300 m in a hypobaric chamber for 30 h (RA). AMS symptom severity was determined by the AMS-cerebral (AMS-C) scores calculated from the daily administration of the Environmental Symptoms Questionnaire during HA and RA.
The mean AMS-C scores were reduced from 0.6 on HA day 1 (HA1) to 0.1 during RA (p < 0.05). Four subjects were "sick" (AMS-C > 0.7) during HA1, while only one was "sick" during RA. The % oxyhemoglobin, hemoglobin concentration and hematocrit were higher during RA compared to HA1.
These results suggest that the retention of acclimatization after 8 d at low altitude is sufficient to attenuate AMS upon reinduction to high altitude.
适应高海拔环境似乎能预防急性高山病（AMS），随着适应过程的推进，AMS症状减轻即为证明。
我们假设部分保留适应状态会在再次进入高海拔地区时减轻AMS的发病率和/或严重程度。
为验证这一假设，6名男性低地居民在4300米（高海拔，HA）适应16天后返回海平面。在海平面（平原，PA）停留8天后，他们在低压舱中再次暴露于4300米环境30小时（再适应，RA）。通过在HA和RA期间每日填写环境症状问卷计算得出的AMS-脑（AMS-C）评分来确定AMS症状的严重程度。
平均AMS-C评分从HA第1天（HA1）的0.6降至RA期间的0.1（p<0.05）。4名受试者在HA1期间“患病”（AMS-C>0.7），而在RA期间只有1名“患病”。与HA1相比，RA期间氧合血红蛋白百分比、血红蛋白浓度和血细胞比容更高。
这些结果表明，在低海拔停留8天后保留的适应状态足以在再次进入高海拔地区时减轻AMS症状。
