Espino A, Calopa M, Ambrosio S, Ortolà J, Peres J, Navarro M A
Department of Neurology, Hospital Prínceps d'Espanya, Spain.
J Neural Transm Park Dis Dement Sect. 1995;9(2-3):189-96. doi: 10.1007/BF02259660.
Somatostatin-like immunoreactivity levels (SLI) in cerebrospinal fluid (CSF) were determined in twenty-three patients with untreated parkinsonian syndrome (15 with Idiopathic Parkinson's disease (IPD) and 8 with other forms of parkinsonism) at the moment of clinical diagnosis (mean duration of disease 1.1 +/- 0.2 years), and in 26 subjects without neurological symptoms. None of the IPD patients had a diagnosis of dementia at the moment of inclusion in the study. CSF-SLI content was found to be significantly higher in patients with parkinsonian syndrome (107.9 +/- 9.8 pg/ml) than in control subjects (73.5 +/- 8.4 pg/ml). The increase was also significant when controls were compared with IPD patients. In addition, a positive correlation between SLI and homovanillic acid was found in CSF of all patients. A test of learning memory was used to evaluate the mental state of patients and a significant increase in CSF-somatostatin levels was observed in patients with Idiopathic Parkinson's disease and severe affectation of memory. These results indicate that in the early steps of untreated parkinsonian syndrome, somatostatin concentration in cerebrospinal fluid may increase, probably due to the neurodegenerative depletion of somatostatin from striatal or cortical neurons.
在临床诊断时（疾病平均病程1.1±0.2年），对23例未经治疗的帕金森综合征患者（15例特发性帕金森病（IPD）和8例其他形式帕金森症）以及26例无神经症状的受试者测定了脑脊液（CSF）中生长抑素样免疫反应水平（SLI）。纳入研究时，IPD患者均未诊断为痴呆。发现帕金森综合征患者的脑脊液SLI含量（107.9±9.8 pg/ml）显著高于对照组（73.5±8.4 pg/ml）。将对照组与IPD患者比较时，这种升高也很显著。此外，在所有患者的脑脊液中发现SLI与高香草酸之间呈正相关。采用学习记忆测试评估患者的精神状态，在特发性帕金森病且记忆严重受损的患者中观察到脑脊液生长抑素水平显著升高。这些结果表明，在未经治疗的帕金森综合征早期，脑脊液中生长抑素浓度可能会升高，这可能是由于纹状体或皮质神经元中生长抑素的神经退行性耗竭所致。
