帕金森病患者脑脊液中生长抑素样免疫反应性及其与痴呆的关系。
Somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with Parkinson's disease and its relation to dementia.
作者信息
Jolkkonen J, Soininen H, Halonen T, Ylinen A, Laulumaa V, Laakso M, Riekkinen P
出版信息
J Neurol Neurosurg Psychiatry. 1986 Dec;49(12):1374-7. doi: 10.1136/jnnp.49.12.1374.
Abstract
Acetylcholinesterase, somatostatin-like immunoreactivity, and homovanillic acid levels were measured in the cerebrospinal fluid of 36 patients with early stages of Parkinson's disease and in 19 control patients. In patients with Parkinson's disease the levels of somatostatin-like immunoreactivity were lower than in the controls (p less than 0.01); these values were lowest in the demented Parkinsonian patients. Concentrations of homovanillic acid were also significantly lower in Parkinsonian patients (p less than 0.05). In contrast, no changes were observed in the acetylcholinesterase activity of patients with Parkinson's disease. The reduced somatostatin-like immunoreactivity in CSF agrees with previous post-mortem studies and indicates that Parkinson's disease and Alzheimer's disease may have some neurochemical features in common.
摘要
在36例帕金森病早期患者及19例对照患者的脑脊液中检测了乙酰胆碱酯酶、生长抑素样免疫反应性和高香草酸水平。帕金森病患者的生长抑素样免疫反应性水平低于对照组（p<0.01）；这些值在帕金森病痴呆患者中最低。帕金森病患者的高香草酸浓度也显著降低（p<0.05）。相比之下，帕金森病患者的乙酰胆碱酯酶活性未观察到变化。脑脊液中生长抑素样免疫反应性降低与先前的尸检研究一致，表明帕金森病和阿尔茨海默病可能有一些共同的神经化学特征。
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