Hayashida N, Han M T, Wu M H, Shi Q, Wechezak A R, Sauvage L R
Hope Heart Institute, Seattle, WA 98122, USA.
Ann Vasc Surg. 1995 Jul;9(4):369-77. doi: 10.1007/BF02139409.
Healing of the inner wall of the same preclotted knitted Dacron arterial prostheses was compared in the descending thoracic aorta (DTA) and the abdominal aorta (AA) of the same dog. Each of 16 dogs received this dual implantation with study periods of 4 weeks for five dogs, 8 weeks for five dogs, and 16 weeks for six dogs. Healing was studied with light microscopy, scanning electron microscopy, transmission electron microscopy, and immunocytochemistry identification. The outer capsule was firmly adherent to the Dacron framework of all grafts implanted in the DTA; advanced healing of the inner wall of all thoracic grafts was present by 4 weeks, nearly complete healing by 8 weeks, and complete healing by 16 weeks. In contrast, the outer capsule was either not attached or only loosely adherent to the Dacron framework in eight AA grafts (50%), and in these implants no healing of the inner wall occurred beyond the limited perianastomotic pannus zone. In the other eight implants in which the outer capsule was firmly adherent to the Dacron framework, healing was roughly comparable to that in the grafts implanted in the DTA. This study demonstrated that (1) DTA grafts heal faster and more completely than AA grafts, (2) healing and endothelialization are related to the tightness of the outer capsule, (3) there is a high incidence of loose tissue attachment in the AA, and (4) healing of aortic grafts is site specific.
在同一只犬的降主动脉（DTA）和腹主动脉（AA）中，比较了预凝血针织涤纶人工血管同一内壁的愈合情况。16只犬均接受了这种双重植入，其中5只犬的研究期为4周，5只犬为8周，6只犬为16周。通过光学显微镜、扫描电子显微镜、透射电子显微镜和免疫细胞化学鉴定来研究愈合情况。外膜牢固地附着于植入DTA的所有移植物的涤纶框架；所有胸段移植物的内壁在4周时出现了进展性愈合，8周时接近完全愈合，16周时完全愈合。相比之下，8个AA移植物（50%）的外膜要么未附着，要么仅松散地附着于涤纶框架，在这些植入物中，除了有限的吻合口周围血管袢区域外，内壁没有愈合。在另外8个外膜牢固附着于涤纶框架的植入物中，愈合情况与植入DTA的移植物大致相当。本研究表明：（1）DTA移植物比AA移植物愈合更快、更完全；（2）愈合和内皮化与外膜的紧密程度有关；（3）AA中组织附着松散的发生率很高；（4）主动脉移植物的愈合具有部位特异性。
