Chabala J C
Phamacopeia Inc, Princeton, USA.
Curr Opin Biotechnol. 1995 Dec;6(6):632-9. doi: 10.1016/0958-1669(95)80104-9.
Encoded combinatorial chemical synthesis on solid phase is a new paradigm in organic chemistry that provides chemists with powers similar to those enjoyed by molecular biologists. Encoded chemical libraries will have a profound impact on all endeavors that seek to identify molecules with optimized properties and to understand the factors governing molecular interactions. In particular, the discovery and optimization of new therapeutic and diagnostic drug molecules, traditionally a slow manual process, will be greatly accelerated by this technology.
固相编码组合化学合成是有机化学中的一种新范例，它为化学家提供了与分子生物学家所拥有的类似的能力。编码化学文库将对所有旨在识别具有优化特性的分子并理解控制分子相互作用的因素的努力产生深远影响。特别是，传统上缓慢的手工过程——新治疗和诊断药物分子的发现与优化，将因这项技术而大大加速。
