透明质酸酶——一组被忽视的酶。
Hyaluronidases--a group of neglected enzymes.
作者信息
Kreil G
机构信息
Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg, Austria.
出版信息
Protein Sci. 1995 Sep;4(9):1666-9. doi: 10.1002/pro.5560040902.
Abstract
Hyaluronan is an important constituent of the extracellular matrix. This polysaccharide can be hydrolyzed by various hyaluronidases that are widely distributed in nature. The structure of some bacterial and animal enzymes of this type has recently been elucidated. It could be shown that the hyaluronidases from bee and hornet venom and the PH-20 hyaluronidase present on mammalian spermatozoa are homologous proteins.
摘要
透明质酸是细胞外基质的重要组成部分。这种多糖可被自然界中广泛分布的各种透明质酸酶水解。最近已阐明了此类一些细菌和动物酶的结构。结果表明，来自蜜蜂和黄蜂毒液的透明质酸酶以及存在于哺乳动物精子上的PH-20透明质酸酶是同源蛋白。
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本文引用的文献
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The hyaluronate synthase from a eukaryotic cell line.来自真核细胞系的透明质酸合酶。
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A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg.精子质膜蛋白PH-20的透明质酸酶活性使精子能够穿透围绕卵子的卵丘细胞层。
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Cloning and nucleotide sequence of the Streptococcus pneumoniae hyaluronidase gene and purification of the enzyme from recombinant Escherichia coli.肺炎链球菌透明质酸酶基因的克隆、核苷酸序列分析及重组大肠杆菌中该酶的纯化
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