Auquier P, Macquart-Moulin G, Moatti J P, Blache J L, Novakovitch G, Blaise D, Faucher C, Viens P, Maraninchi D
INSERM, Institut Paoli-Calmettes, Marseille, France.
Bone Marrow Transplant. 1995 Oct;16(4):541-7.
The aim of this study was to compare anxiety, pain and discomfort of cancer patients submitted to either peripheral blood progenitor cell collection (PBPCC) or bone marrow harvest (BMH). Patients, randomized (7/1993-2/1994), in view of autograft, to receive the first procedure or the second one, completed self-administered questionnaires. Anxiety was assessed by the State Trait Anxiety Inventory and pain using visual analogical scale (VAS) and McGill Pain questionnaire. Before the procedure, BMH patients (n = 25) experienced more anxiety (P < 0.01) and more trouble or inconvenience for having to come and stay at the hospital (P < 0.0001) than PBPCC patients (n = 40). Pain due to BMH is significantly higher than pain induced by PBPCC (P < 0.001 for VAS and total McGill score). However, patients submitted to PBPCC with a femoral catheter (n = 19) had significantly higher total McGill scores and sensory sub-scores than patients without it (n = 21). At discharge from the hospital, PBPCC patients expressed more positive judgements towards the collection procedure than BMH patients. These results suggest that a better patient acceptability of high-dose chemotherapy followed by autograft may be obtained by substituting PBPCC for BMH for stem cell collection.
本研究旨在比较接受外周血祖细胞采集（PBPCC）或骨髓采集（BMH）的癌症患者的焦虑、疼痛和不适情况。鉴于自体移植，患者于1993年7月至1994年2月被随机分配接受第一种或第二种操作，并完成自我管理问卷。焦虑通过状态特质焦虑量表进行评估，疼痛使用视觉模拟量表（VAS）和麦吉尔疼痛问卷进行评估。在操作前，BMH患者（n = 25）比PBPCC患者（n = 40）经历了更多焦虑（P < 0.01），并且因必须前来并留在医院而感到更多困扰或不便（P < 0.0001）。BMH导致的疼痛显著高于PBPCC引起的疼痛（VAS和麦吉尔总分的P < 0.001）。然而，接受带股静脉导管的PBPCC的患者（n = 19）的麦吉尔总分和感觉子分数显著高于未带导管的患者（n = 21）。在出院时，PBPCC患者对采集过程的评价比BMH患者更积极。这些结果表明，用PBPCC替代BMH进行干细胞采集可能会使高剂量化疗后自体移植的患者接受度更高。
